Research-Informed • Endocrinology & Incretin Pharmacology • Patient-Led Sovereignty
Her Metabolic Health Clinical Intelligence & Shared Agency
The Metabolic Paradigm Shift

Stop Waiting for Authority. Start Leading Your Care.

Obesity is a complex, biological neuro-endocrine signaling disorder, not a moral defect of discipline. Telehealth medicine promised convenience, but decentralized clinical coordination, leaving patients with 100% of the daily responsibility and 0% of the operational tools. Her Metabolic Health bridges the chasm between endocrinology and sovereign execution.

Explore The Framework Access The Clinical Tools
The unLit Thesis
“You do not apologize for taking blood pressure medicine when your pressure normalizes. You do not apologize for administering an endocrine hormone peptide when your metabolic engine is finally functioning.”
, Cat Clark, Author of FAT BITCH
Operational Infrastructure

The Three Pillars of Shared Agency

The Shared Agency Framework (SAF) is a structured model replacing passive patient compliance with active, data-driven partnership between patient and clinician.

01

Biology

Deconstruct incretin pharmacology, the neurobiology of hypothalamic food noise, insulin resistance mechanisms, and delayed gastric emptying. Biology dictates the terrain; data dictates the strategy.

Explore Incretin Science →
02

Environment

Audit the systemic forces undermining your health: ultra-processed food industrialization, insurance prior authorization denial schemes, and pharmacy access hurdles across brand and compounding sources.

Audit The System →
03

Action

Operationalize daily survival: hit the Leucine Anchor to defend lean muscle mass, use food sequencing to ease slowed digestion, and use word-for-word scripts to dismantle doctor bias.

View Daily Protocols →
Built on Peer-Reviewed Trials

Featured Clinical Intelligence

Neurobiology of Appetite

The Food Noise Autopsy: Hypothalamic Dopamine & Incretin Signaling

Why the constant mental loop of "food noise" is tied to appetite and reward signaling in the brain, not character, and how GLP-1 receptor agonists turn that signal down for many patients.

Read Clinical Breakdown →
Muscle Preservation

The Leucine Anchor: Protecting Muscle on GLP-1s

In the major trials, roughly a quarter to two fifths of the weight lost on GLP-1s was lean mass, which includes muscle. How to trigger muscle protein synthesis with a target of about 2.5 to 3.0g of leucine per meal.

Read Fueling Protocol →
GI Mechanics & Motility

Slowed Digestion & The Vagus Nerve: Nausea as High-Priority Data

Slower stomach emptying is one of several drug effects and is strongest in the early weeks. How to sequence meals for comfort, and which symptoms mean you call your prescriber the same day.

Explore Motility Protocol →
Pharmacy & Sourcing Safety

503A vs. 503B Compounding: Molecule Stability and Base vs. Salt

Navigating the regulatory landscape of compounded Semaglutide and Tirzepatide after the 2024 and 2025 shortage resolutions. Critical criteria for Certificates of Analysis (COA) and sterility verification.

Read Sourcing Guide →
Peer Community  ·  Moderated

The Record This Site Does Not Keep

Her Metabolic Health documents mechanism, dosing and biomarkers. It does not document what week eleven actually feels like. That record is kept separately, and deliberately, at Bitches & Besties, a moderated peer community for people on GLP-1 therapy, organized by the month a member started or restarted treatment, so that a timeline is compared against a matched timeline rather than against a stranger’s.

Visit Bitches & Besties → Enter the Community Forum →
Patient & Clinician Toolkits

The Proprietary Tools Vault

Evidence-based, printable worksheets and diagnostic algorithms engineered for patient advocacy and structured physician consultations.

Advanced Lab Panel Request Guide

Printable checklist of fasting insulin, HOMA-IR, ApoB, and visceral adiposity markers standard panels overlook.

Download PDF Guide

Weight Loss Stall Diagnostic

4-step diagnostic algorithm to tell an expected plateau apart from a dose that may need review with your prescriber.

Download Diagnostic

Protein & Muscle Worksheet

Formulas to calculate a starting protein target of about 1.2g/kg (ask your clinician which body weight to use) and track daily leucine thresholds across meals.

Download Worksheet

Second Brain Motility & Nausea Log

A daily log to track fullness, nausea and bowel habits, adjust food sequencing, and spot symptoms that need your prescriber.

Download Log
The Literature & Daily Companion

Fat Bitch & The Anti-Diet GLP-1 Tracker

The radical, unapologetic movement that birthed the Shared Agency Framework. Cat Clark translates clinical endocrinology into plain language, paired with the official Anti-Diet GLP-1 Tracker (coming soon), which will put injection logs, the food-noise dial, and patient advocacy toolkits directly into your pocket.

Visit The Book Site → Join the Anti-Diet GLP-1 Tracker Early-Access List →
4.7 / 5.0 Verified NetGalley Rating
“This should be The GLP-1 Virgin’s Handbook. Invest in this book no matter where you are in your journey.”
Edie Myers, Reviewer

Sources

Last reviewed October 19, 2026 by Cat Clark, curator. Every claim on this page traces to one of these records. Research evolves, and a study population is not you.

  1. Wilding JPH, et al. Once-Weekly Semaglutide in Adults with Overweight or Obesity (STEP 1). N Engl J Med. 2021;384(11):989-1002. doi.org
  2. Jastreboff AM, et al. Tirzepatide Once Weekly for the Treatment of Obesity (SURMOUNT-1). N Engl J Med. 2022. doi.org
  3. U.S. Food and Drug Administration. FDA clarifies policies for compounders as national GLP-1 supply begins to stabilize. February 21, 2025. fda.gov
  4. U.S. Food and Drug Administration. Resolution of Semaglutide Injection Product Shortage and Supply Status (decision memorandum). February 21, 2025. fda.gov
  5. U.S. Food and Drug Administration. List of Bulk Drug Substances for Which There Is a Clinical Need Under Section 503B: proposal to exclude semaglutide, tirzepatide and liraglutide. 91 Fed. Reg. 23431, May 1, 2026 (proposed, not final). Summary by Epstein Becker Green. ebglaw.com
  6. Bauer J, et al. Evidence-Based Recommendations for Optimal Dietary Protein Intake in Older People: A Position Paper From the PROT-AGE Study Group. J Am Med Dir Assoc. 2013;14(8):542-559. doi.org
  7. Peer-reviewed review of protein meal distribution and the leucine threshold for muscle protein synthesis. PubMed Central, PMC11099237. pmc.ncbi.nlm.nih.gov